2017年

5月11日

投稿者 : yoshimura1212 投稿日時: 2017-05-11 16:34:03 (1372 ヒット)

 先ほど免疫学会からまわってきたお知らせメールで大学院生(だった)駒井さんのII論文が『今月の注目論文』に選ばれたことを知った。やっぱりIIではもったいなかったか?来月、学位審査で本人は今から緊張しているので少しは「追い風」になってくれたかもしれない。それにしてもEditor’s Choiceの英語が何か変では。。。
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今回の注目論文は、慶應大学の駒井恭子先生らによる論文、
“Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation”
です。こちらは、Editor’s Choiceとして選ばれ、2月号に掲載されています。
https://academic.oup.com/intimm/article/doi/10.1093/intimm/dxx010/3051985/Role-of-scavenger-receptors-as-damage-associated


“Macrophage scavenger receptors bind HMGB1 and are co-receptors for TLR4”
by Kyoko Komai et al.
https://academic.oup.com/intimm/article/doi/10.1093/intimm/dxx010/3051985/Role-of-scavenger-receptors-as-damage-associated 
HMGB1 has many important functions in the cell nucleus but can be secreted and recognized as a damage-associated molecular pattern (DAMP), e.g. in LPS-induced shock and DSS-induced colitis. Such ‘danger signals’ are recognized by e.g. RAGEs, TLRs and so-called ‘scavenger receptors’, which bind a range of ligands; class A scavenger receptors are mostly expressed on macrophages. HMGB1 is known to bind RAGEs and various TLRs but only binds e.g. TLR4 with low affinity. HMGB1-mediated inflammation is mostly delivered via macrophages, which have two functionally distinct categories (M1 and M2). In their paper, Komai et al. show that HMGB1 is efficiently internalized by M1 and M2 macrophages via various class A scavenger receptors; only M1 macrophages secrete cytokines, though. Scavenger receptors are also required as co-receptors for efficient HMGB1-mediated TLR4 activation and internalization. In vivo, a scavenger receptor antagonist (M-BSA) reduces the lethality caused by LPS and ameliorates DSS-induced colitis.

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