トップ  >  publications

   (2009) 

SOCS3 in T and NKT Cells Negatively Regulates Cytokine Production and Ameliorates ConA-Induced Hepatitis. Nakaya M, Hashimoto M, Nakagawa R, Wakabayashi Y, Ishizaki T, Takada I, Komai K, Yoshida H, Yoshimura A. J Immunol. 2009 Dec 1;183(11):7047-7053. Epub 2009 Nov 13.

Clinical and Mutational Spectrum of Neurofibromatosis Type 1-like Syndrome. Messiaen L, Yao S, Brems H, Callens T, Sathienkijkanchai A, Denayer E, Spencer E, Arn P, Babovic-Vuksanovic D, Bay C, Bobele G, Cohen BH, Escobar L, Eunpu D, Grebe T, Greenstein R, Hachen R, Irons M, Kronn D, Lemire E, Leppig K, Lim C, McDonald M, Narayanan V, Pearn A, Pedersen R, Powell B, Shapiro LR, Skidmore D, Tegay D, Thiese H, Zackai EH, Vijzelaar R, Taniguchi K, Ayada T, Okamoto F, Yoshimura A, Parret A, Korf B, Legius E. JAMA. 2009 Nov 18;302(19):2111-2118.

Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med. 2009 Sep 28;206(10):2067-77. 

Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A.  Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nature Med. 2009 Aug;15(8):946-50.

Yoshimura A. Regulation of cytokine signaling by the SOCS and Spred family proteins.  Keio J Med. 2009 Jun;58(2):73-83.

Yoshimura A. Stat1 phosphorylation is a molecular switch of Ras signaling and oncogenesis.  Cell Cycle. 2009 Jul 1;8(13):1981-2.

Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Sugiyama Y, Komai K, Saba I, Möröy T, Yoshimura A.  Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity.  Int Immunol. 2009 Jul;21(7):881-9

Taniguchi K, Ishizaki T, Ayada T, Sugiyama Y, Wakabayashi Y, Sekiya T, Nakagawa R, Yoshimura A.  Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. Cancer Sci. 2009 Sep;100(9):1648-54

Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A.  Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis. PLoS ONE. 2009;4(5):e5467. 

Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, Guan KL, Yoshimura A. The mTOR pathway is highly activated in Diabetic Nephropathy and Rapamycin has a strong therapeutic potential  Biochem Biophys Res Commun. 2009 Jul 10;384(4):471-5. 

Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A. A major lipid raft protein raftlin modulates T cell receptor signaling and enhances Th17-mediated autoimmune responses. J Immunol. 2009 May 15;182(10):5929-37.

Sekine Y, Yamamoto C, Ikeda O, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. . Biochem Biophys Res Commun. 2009 Jun 26;384(2):187-92.

Ikeda O, Miyasaka Y, Sekine Y, Mizushima A, Muromoto R, Nanbo A, Yoshimura A, Matsuda T.  STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation. Biochem Biophys Res Commun. 2009 Jun 19;384(1):71-5.

Fukuyama S, Nakano T, Matsumoto T, Oliver BG, Burgess JK, Moriwaki A, Tanaka K, Kubo M, Hoshino T, Tanaka H, McKenzie AN, Matsumoto K, Aizawa H, Nakanishi Y, Yoshimura A, Black JL, Inoue H. Pulmonary Suppressor of Cytokine Signaling (SOCS)-1 Induced by IL-13 Regulates Allergic Asthmatic Phenotype. Am J Respir Crit Care Med. 2009 Jun 1;179(11):992-8

Kobayashi T, Kim TS, Jacob A, Walsh MC, Kadono Y, Fuentes-Pananá E, Yoshioka T, Yoshimura A, Yamamoto M, Kaisho T, Akira S, Monroe JG, Choi Y. TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS ONE. 2009;4(3):e4736

Hashimoto M, Ayada T, Kinjyo I, Hiwatashi K, Yoshida H, Okada Y Kobayashi T and Yoshimura A. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation Cancer Sci 2009 Apr;100(4):730-6.

Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A. Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the c-Fos protein phosphorylated by IKKbeta Immunity 2009 30(3): 372-383

Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009 Jan;30(1):80-91.

Hikata T, Takaishi H, Takito J, Hakozaki A, Furukawa M, Uchikawa S, Kimura T, Okada Y, Matsumoto M, Yoshimura A, Nishimura R, Reddy SV, Asahara H, Toyama Y. PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts. Blood 2009 Mar 5;113(10):2202-12.

Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. Biochem Biophys Res Commun. 2009 Apr 10;381(3):412-7.

Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A, Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis. Oncogene. 2009 Feb 26;28(8):1076-88.

Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, Kobayashi T, Yoshida H, Yoshimura A. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford). 2009 Apr;48(4):347-54.

Atsumi T, Sato M, Kamimura D, Moroi A, Iwakura Y, Betz UA, Yoshimura A, Nishihara M, Hirano T, Murakami M. IFN-gamma expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int Immunol. 2009 Jan;21(1):73-80..

(2008)-22
Denayer E, Ahmed T, Brems H, Van Woerden G, Borgesius NZ, Callaerts-Vegh Z, Yoshimura A, Hartmann D, Elgersma Y, D'Hooge R, Legius E, Balschun D. Spred1 is required for synaptic plasticity and hippocampus-dependent learning. J Neurosci. 2008 Dec 31;28(53):14443-9.

Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T. TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway. J Biol Chem. 2008 Dec 26;283(52):36211-20. 

Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A.  FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicases signaling pathway. J Biol Chem. 2008 Dec 5;. 283(49):33858-64.

Miyamoto K, Miyamoto T, Kato R, Yoshimura A, Motoyama N, Suda T.  FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging. Blood. 2008 Dec 1;112(12):4485-93.

Sitko JC, Yeh B, Kim M, Zhou H, Takaesu G, Yoshimura A, McBride WH, Jewett A, Jamieson CA, Cacalano NA. SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cell Signal. 2008 Dec;20(12):2221-30.

Ikeda O, Sekine Y, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T.  Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice.  Biol Pharm Bull. 2008 Sep;31(9):1790-3.

Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS.  Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008 Nov;149(11):5654-61. 

Shiraishi H, Yoshida H, Saeki K, Miura Y, Watanabe S, Ishizaki T, Hashimoto M, Takaesu G, Kobayashi T, Yoshimura A.  Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells. Int Immunol. 2008 Sep;20(9):1219-29. Epub 2008 Jul 17.

Ozawa Y, Nakao K, Kurihara T, Shimazaki T, Shimmura S, Ishida S, Yoshimura A, Tsubota K, Okano H.  Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. J Biol Chem. 2008 Sep 5;283(36):24561-70. 

Ikeda O, Sekine Y, Yasui T, Oritani K, Sugiyma K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T. STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1. Mol Cell Biol. 2008 Aug;28(16):5027-42. 

Haffner MC, Jurgeit A, Berlato C, Geley S, Parajuli N, Yoshimura A, Doppler W. Interaction and functional interference of glucocorticoid receptor and SOCS1. J Biol Chem. 2008 283(32):22089-96.

Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.  J Biol Chem. 2008 Jun 20;283(25):17003-8.

Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T. STAT6 inhibits TGF-beta 1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem. 2008 May 30;283(22):14955-62

Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A. Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. Hepatology. 2008 Jan 14;47(5):1644-1654

Horino J, Fujimoto M, Terabe F, Serada S, Takahashi T, Soma Y, Tanaka K, Chinen T, Yoshimura A, Nomura S, Kawase I, Hayashi N, Kishimoto T, Naka T. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int Immunol. 2008 Jun;20(6):753-62.

Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A. Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads. J Immunol. 2008 Mar 15;180(6):3746-56.

Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, Chinen T, Inaba T, Hikida M, Kurosaki T, Saeki K, Yoshimura A. Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells. Genes Cells. 2008 Feb;13(2):199-208.

Zhu BM, Ishida Y, Robinson GW, Pacher-Zavisin M, Yoshimura A, Murphy PM, Hennighausen L. SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing. J Invest Dermatol. 2008 Jul;128(7):1821-9

Ryo A, Tsurutani N, Ohba K, Kimura R, Komano J, Nishi M, Soeda H, Hattori S, Perrem K, Yamamoto M, Chiba J, Mimaya J, Yoshimura K, Matsushita S, Honda M, Yoshimura A, Sawasaki T, Aoki I, Morikawa Y, Yamamoto N. SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):294-9.

 

Yoshimura T, Sonoda KH, Miyazaki Y, Iwakura Y, Ishibashi T, Yoshimura A, Yoshida H. Differential roles for IFN-{gamma} and IL-17 in experimental autoimmune uveoretinitis. Int Immunol. 2008 Feb;20(2):209-14

 

Sugiyama N, Nakashima H, Yoshimura T, Sadanaga A, Shimizu S, Masutani K, Igawa T, Akahoshi M, Miyake K, Takeda A, Yoshimura A, Hamano S, Yoshida H. Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of IL-27R{alpha} (WSX-1). Ann Rheum Dis. 2008 Oct;67(10):1461-7.

 

Yu Q, Minoda Y, Yoshida R, Yoshida H, Iha H, Kobayashi T, Yoshimura A, Takaesu G. HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein. Biochem Biophys Res Commun. 2008 Jan 4;365(1):189-94. 

 

(2007)-18

 

Yoshimura A., Naka, T., Kubo, M., SOCS proteins, cytokine signalling and immune regulation. 

Nature Review Immunology.  2007 Jun;7(6):454-65.

 

Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE. SOCS3 Protein Developmentally Regulates the Chemokine Receptor CXCR4-FAK Signaling Pathway during B Lymphopoiesis. Immunity. 2007 Nov 26;27(5):811-823.

 

Brems H, Chmara M, Sahbatou M, Denayer E, Taniguchi K, Kato R, Somers R, Messiaen L, De Schepper S, Fryns JP, Cools J, Marynen P, Thomas G, Yoshimura A, Legius E. Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. Nature Genet. 2007 Sep;39(9):1120-6. 

 

Yamauchi M, Hashimoto M, Ichiyama K, Yoshida R, Hanada T, Muta T, Komune S, Kobayashi T, Yoshimura A. Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Int Immunol. 2007 Aug;19(8):935-42. 

 

Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, Shimoda K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T. Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase. J Immunol. 2007 Aug 15;179(4):2397-407.

 

Matsumura Y, Kobayashi T, Ichiyama K, Yoshida R, Hashimoto M, Takimoto T, Tanaka K, Chinen T, Shichita T, Wyss-Coray T, Sato K, Yoshimura A. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J Immunol. 2007 Aug 15;179(4):2170-9.

 

Mori H, Shichita T, Yu Q, Yoshida R, Hashimoto M, Okamoto F, Torisu T, Nakaya M, Kobayashi T, Takaesu G, Yoshimura A. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. 

 

Ikeda O, Sekine Y, Kakisaka M, Tsuji S, Muromoto R, Ohbayashi N, Oritani K, Yoshimura A, Matsuda T. STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells. Biochem Biophys Res Commun. 2007 Jul 6;358(3):931-7. 

 

Fukuda S, Abematsu M, Mori H, Yanagisawa M, Kagawa T, Nakashima K, Yoshimura A, Taga T. Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells.  Mol Cell Biol. 2007 Jul;27(13):4931-7. 

 

Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, Oike Y, Yonemitsu Y, Maehara Y, Yoshimura A. Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol. 2007 Jun;27(12):4541-50.

 

Zhou H, Miki R, Eeva M, Fike FM, Seligson D, Yang L, Yoshimura A, Teitell MA, Jamieson CA, Cacalano NA. Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. Clin Cancer Res. 2007 Apr 15;13(8):2344-53.

 

Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, Onodera M, Yoshimura A, Kobayashi T. An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity. Int Immunol. 2007 May;19(5):609-19. 

 

Sekine Y, Tsuji S, Ikeda O, Kakisaka M, Sugiyama K, Yoshimura A, Matsuda T.  Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity. Biochem Biophys Res Commun. 2007 May 4;356(2):517-22. 

 

Yoshiga D, Sato N, Torisu T, Mori H, Yoshida R, Nakamura S, Takaesu G, Kobayashi T, Yoshimura A. Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels. Mol Endocrinol. 2007 May;21(5):1120-31. 

 

Torisu T, Sato N, Yoshiga D, Kobayashi T, Yoshioka T, Mori H, Iida M, Yoshimura A. The dual function of hepatic SOCS3 in insulin resistance in vivo. Genes Cells. 2007 Feb;12(2):143-54.

 

Shudo E, Yang J, Yoshimura A, Iwasa Y. Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps.  J Theor Biol. 2007 May 7;246(1):1-9. 

 

Robinson GW, Pacher-Zavisin M, Zhu BM, Yoshimura A, Hennighausen L. Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis. Dev Dyn. 2007 Mar;236(3):654-61.

 

Ozawa Y, Nakao K, Shimazaki T, Shimmura S, Kurihara T, Ishida S, Yoshimura A, Tsubota K, Okano H.

SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Dev Biol. 2007 Mar 15;303(2):591-600. .

 

Taniguchi K, Ayada T, Ichiyama K, Kohno R, Yonemitsu Y, Minami Y, Kikuchi A, Maehara Y, Yoshimura A. Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.  Biochem Biophys Res Commun. 2007 Jan 26;352(4):896-902. 

 

(2006) -26

Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28;114(22):2364-73.

 

Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. J Biol Chem. 2006 Dec 1;281(48):36683-90.

 

Yoshimura T, Takeda A, Hamano S, Miyazaki Y, Kinjyo I, Ishibashi T, Yoshimura A, Yoshida H. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.  J Immunol. 2006 Oct 15;177(8):5377-85.

 

Shiraishi H, Okamoto H, Yoshimura A, Yoshida H. ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.  J Cell Sci. 2006 Oct 1;119(Pt 19):3958-66

 

Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature Immunol. 2006 Sep;7(9):937-45.

 

Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.  Cell Metab. 2006 Aug;4(2):123-32

 

Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A, Kobayashi T. TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.  Genes Cells. 2006 Aug;11(8):871-82. 

 

Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology. 2006 Jul;131(1):179-93. 

 

Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.  Nature Med. 2006 Jul;12(7):829-34.

 

Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.    J Exp Med. 2006 Jun 12;203(6):1391-7.

 

Yamagishi S, Nakamura K, Matsui T, Inagaki Y, Takenaka K, Jinnouchi Y, Yoshida Y, Matsuura T, Narama I, Motomiya Y, Takeuchi M, Inoue H, Yoshimura A, Bucala R, Imaizumi T. Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression. J Biol Chem. 2006 Jul 21;281(29):20213-20.

 

Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med. 2006 Apr 17;203(4):1021-31.

 

Chen Z, Laurence A, Kanno Y, Pacher-Zavisin M, Zhu BM, Tato C, Yoshimura A, Hennighausen L, O'Shea JJ. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8137-42.

 

Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M.Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. Oncogene. 2006 Oct 5;25(45):6056-66.

 

Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A.  A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30

 

Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. Oncogene. 2 006 Apr 20;25(17):2520-30. 

 

Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Hashimoto M, Yagita H, Nawata H, Yoshimura A. Suppressor of Cytokine Signaling-1 Regulates Inflammatory Bowel Disease in Which Both IFNgamma and IL-4 Are Involved.  Gastroenterology. 2006;130: 373-388.

 

Moriyama M, Matsukawa A, Kudoh S, Takahashi T, Sato T, Kano T, Yoshimura A, Kojima M. The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock. Biochem Biophys Res Commun. 2006 Jan 26;341(4):1149-1154

 

Ni R, Ihara K, Miyako K, Takemoto M, Ishimura M, Kohno H, Matsuura N, Yoshimura A, Hara T.  Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus.  Int J Immunogenet. 2006; 33: 7-10. 

 

Yamada S, Tsukada J, Yoshimura A, Kubo M. Computer simulation of the role of SOCS family protein in helper T cell differentiation. Int Immunol. 2006;18: 335-345.

 

Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I. Involvement of a novel Q-SNARE, D12, in quality control of endomembrane system. J Biol Chem. 2006 281:4495-4506

 

Qasimi P, Ming-Lum A, Ghanipour A, Ong CJ, Cox ME, Ihle J, Cacalano N, Yoshimura A, Mui AL. Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumour necrosis factor alpha and nitric oxide production by macrophages.  J Biol Chem. 2006, 281(10):6316-24.

 

Moriyama M, Fukuyama S, Inoue H, Matsumoto T, Sato T, Tanaka K, Kinjyo I, Kano T, Yoshimura A, Kojima M. The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L971-7.

 

Shouda T, Hiraoka K, Komiya S, Hamada T, Zenmyo M, Iwasaki H, Isayama T, Fukushima N, Nagata K, Yoshimura A. Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells. Cancer Lett. 2006; 231:176-184.

 

Inagaki-Ohara K, Sasaki A, Matsuzaki G, Ikeda T, Hotokezaka M, Chijiiwa K, Kubo M, Yoshida H, Nawa Y, Yoshimura A. Suppressor of cytokine signalling-1 in lymphocytes regulates the development of intestinal inflammation in mice. Gut. 2006; 55: 212-219.

 

Sekine Y, Yumioka T, Yamamoto T, Muromoto R, Imoto S, Sugiyma K, Oritani K, Shimoda K, Minoguchi M, Akira S, Yoshimura A, Matsuda T. Modulation of TLR4 Signaling by a Novel Adaptor Protein Signal-Transducing Adaptor Protein-2 in Macrophages. J Immunol. 2006; 176: 380-389. 

 

(2005) 

Tanimoto K, Saito Y, Hamanaka I, Kuwahara K, Harada M, Takahashi N, Kawakami R, Nakagawa Y, Nakanishi M, Adachi Y, Shirakami G, Fukuda K, Yoshimura A, Nakao K. SOCS1/JAB Likely Mediates the Protective Effect of Cardiotrophin-1 Against Lipopolysaccharide-Induced Left Ventricular Dysfunction In Vivo.  Circ J. 2005 69:1412-1417. 

 

Mashima R, Saeki K, Aki D, Minoda Y, Takaki H, Sanada T, Kobayashi T, Aburatani H, Yamanashi Y, Yoshimura A. FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.  J Biol Chem. 2005 ;280: 41289-41297.

 

Tokumaru S, Sayama K, Shirakata Y, Komatsuzawa H, Ouhara K, Hanakawa Y, Yahata Y, Dai X, Tohyama M, Nagai H, Yang L, Higashiyama S, Yoshimura A, Sugai M, Hashimoto K.: Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37.  J Immunol. 2005;175: 4662-4668.

 

Miyazaki Y, Inoue H, Matsumura M, Matsumoto K, Nakano T, Tsuda M, Hamano S, Yoshimura A, Yoshida H. Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice.. J Immunol. 2005 ;175: 2401-2407. 

 

Nonami A, Taketomi T, Kimura A, Saeki K, Takaki H, Sanada T, Taniguchi K, Harada M, Kato R, Yoshimura A.  The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. Genes Cells. 2005 ; 10: 887-895.

 

Moriyama M, Sato T, Inoue H, Fukuyama S, Teranishi H, Kangawa K, Kano T, Yoshimura A, Kojima M. The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. J Exp Med. 2005;202: 217-224.

 

Takeda A, Hamano S, Shiraishi H, Yoshimura T, Ogata H, Ishii K, Ishibashi T, Yoshimura A, Yoshida H.  WSX-1 over-expression in CD4+ T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation. Int Immunol. 2005, 17: 889-897;

 

Tsukada J, Ozaki A, Hanada T, Chinen T, Abe R, Yoshimura A, Kubo M.  The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8{alpha}+ dendritic cell subset. Int Immunol. 2005;17:1167-78.

 

Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, Sasaki M, Sasaki A, Ishibashi H, Moriyama M, Nakamura KI, Nishimura J, Yoshimura A. Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nature Neurosci. 2005 8, 855-857

 

Takatori H, Nakajima H, Kagami S, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I. Stat5a Inhibits IL-12-Induced Th1 Cell Differentiation through the Induction of Suppressor of Cytokine Signaling 3 Expression.  J Immunol. 2005;174:4105-4112. 

 

Aki D, Mashima R, Saeki K, Minoda Y, Yamauchi M, Yoshimura A. Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages. Genes Cells. 2005;10:357-368.

 

Hanada T, Tanaka K, Matsumura Y, Yamauchi M, Nishinakamura H, Aburatani H, Mashima R, Kubo M, Kobayashi T, Yoshimura A. Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene. J Immunol. 2005;174:4325-4332.

 

Ohishi M, Matsumura Y, Aki D, Mashima R, Taniguchi K, Kobayashi T, Kukita T, Iwamoto Y, Yoshimura A. Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines.  J Immunol. 2005 ;174:3024-3031.

 

Inoue H, Kato R, Fukuyama S, Nonami A, Taniguchi K, Matsumoto K, Nakano T, Tsuda M, Matsumura M, Kubo M, Ishikawa F, Moon BG, Takatsu K, Nakanishi Y, Yoshimura A. Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. J Exp Med.;201:73-82, 2005. 

 

Tokumaru S, Sayama K, Yamasaki K, Shirakata Y, Hanakawa Y, Yahata Y, Dai X, Tohyama M, Yang L, Yoshimura A, Hashimoto K.  SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration. Biochem Biophys Res Commun. 327:100-105, 2005 

 

Takahashi N, Saito Y, Kuwahara K, Harada M, Tanimoto K, Nakagawa Y, Kawakami R, Nakanishi M, Yasuno S, Usami S, Yoshimura A, Nakao K.  Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes.  J Mol Cell Cardiol. 38:185-192, 2005 

 

Sekine Y, Yamamoto T, Yumioka T, Sugiyama K, Tsuji S, Oritani K, Shimoda K, Minoguchi M, Yoshimura A, Matsuda T.  Physical and functional interactions between STAP-2/BKS and STAT5. J Biol Chem. 2005;280:8188-8196.

 

(2004) 

Kawaguchi T, Yoshida T, Harada M, Hisamoto T, Nagao Y, Ide T, Taniguchi E, Kumemura H, Hanada S, Maeyama M, Baba S, Koga H, Kumashiro R, Ueno T, Ogata H, Yoshimura A, Sata M.  Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3. Am J Pathol. 165:1499-1508, 2004

 

Yamagishi S, Abe R, Inagaki Y, Nakamura K, Sugawara H, Inokuma D, Nakamura H, Shimizu T, Takeuchi M, Yoshimura A, Bucala R, Shimizu H, Imaizumi T Minodronate, a newly developed nitrogen-containing bisphosphonate, suppresses melanoma growth and improves survival in nude mice by blocking vascular endothelial growth factor signaling.  Am J Pathol.;165:1865-18674, 2004.

 

Yamagishi S, Inagaki Y, Nakamura K, Abe R, Shimizu T, Yoshimura A, Imaizumi T. Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. J Mol Cell Cardiol. 2004 Aug;37(2):497-506.

 

Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A, Saito N.  Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem Biophys Res Commun. 325:843-851, 2004.

 

Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A. Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.  J Biol Chem. 279:52543-52551, 2004.

 

Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y, Yoshimura A.  Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J Immunol. 173:1390-1398, 2004.

 

Miyoshi K, Wakioka T, Nishinakamura H, Kamio M, Yang L, Inoue M, Hasegawa M, Yonemitsu Y, Komiya S, Yoshimura A. The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. Oncogene. 23: 5567-5576, 2004.

 

Kazemi S, Papadopoulou S, Li S, Su Q, Wang S, Yoshimura A, Matlashewski G, Dever TE, Koromilas AE. Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol. 24:3415-34129, 2004.

 

.Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, and Yoshimura A SOCS3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity Nature Mediciene 10: 739-743, 2004

 

Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai, H and Yoshimura A  SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis  J Exp Med. 199: 1701-1707, 2004

 

Murakoshi H, Iino R, Kobayashi T, Fujiwara T, Ohshima C, Yoshimura A, Kusumi A.Single-molecule imaging analysis of Ras activation in living cells. Proc Natl Acad Sci U S A. 101; 7317-7322, 2004

 

Yamada S, Taketomi T, Yoshimura A. Model analysis of difference between EGF pathway and FGF pathway. Biochem Biophys Res Commun. 314:1113-1120, 2004. 

 

Nobuhisa I, Kato R, Inoue H, Takizawa M, Okita K, Yoshimura A, Taga T.  Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation.  J Exp Med. 199:737-742, 2004.

 

Kamio M, Yoshida T, Ogata H, Douchi T, Nagata Y, Inoue M, Hasegawa M, Yonemitsu Y, Yoshimura A. SOCS1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein. Oncogene 17,3108-3116, 2004

 

Qu L, Huang S, Baltzis D, Rivas-Estilla AM, Pluquet O, Hatzoglou M, Koumenis C, Taya Y, Yoshimura A, Koromilas AE.  Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3{beta}  Genes Dev. 18:261-277, 2004. 

 

Gatto L, Berlato C, Poli V, Tininini S, Kinjyo I, Yoshimura A, Cassatella MA, Bazzoni F. Analysis of suppressor of cytokine signaling (SOCS)-3 promoter responses to interferon. J Biol Chem. 279:13746-13754, 2004

 

Joo A, Aburatani H, Morii E, Iba H, Yoshimura A. STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.  Oncogene., 23: 726-734, 2004.

 

Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A.  SOCS3 is a physiological negative regulator for granulopoiesis and G-CSF receptor signaling. J Biol Chem.  297; 6905-6910, 2004

 

Fischer P, Lehmann U, Sobota RM, Schmitz J, Niemand C, Linnemann S, Haan S, Behrmann I, Yoshimura A, Johnston JA, Muller-Newen G, Heinrich PC, Schaper F. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitisation of interleukin-6 signalling.

Biochem J.  378: 449-460, 2004

 

Yamanaka A, Hamano S, Miyazaki Y, Ishii K, Takeda A, Mak TW, Himeno K, Yoshimura A, Yoshida H. Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis.  J Immunol. 2004;172: 3590-3596.

 

(2003) -25

Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol. 2003, 4: 1169-1176. 

 

Yoshimura A, Mori H, Ohishi M, Aki D, Hanada T.  Negative regulation of cytokine signaling influences inflammation. Curr Opin Immunol. 2003, 15: 704-708. 

 

Inagaki-Ohara K, Hanada T, Yoshimura A.  Negative regulation of cytokine signaling and inflammatory diseases.  Curr Opin Pharmacol. 2003, 3;  435-442. 

 

Hamano S, Himeno K, Miyazaki Y, Ishii K, Yamanaka A, Takeda A, Zhang M, Hisaeda H, Mak TW, Yoshimura A, Yoshida H. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity. 2003, 19: 657-667.

 

Hanada T, Yoshida H, Kato S, Tanaka K, Masutani K, Tsukada J, Nomura Y, Mimata H, Kubo M, Yoshimura A. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity. 2003; 19: 437-450. 

 

Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano N, O'Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M.: SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses Nature Medicine 2003, 9, 1047-1054

 

Yamamoto T, Yumioka T, Sekine Y, Sato N, Minoguchi M, Yoshimura A, Matsuda T. Regulation of Fc varepsilon RI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. Biochem Biophys Res Commun. 2003 ;306:767-773.

 

Yasukawa H, Ohishi M,  Mori H,  Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, and Yoshimura A; IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages Nature Immunol. 2003; 4, 551-556

 

Saeki K,  Miura Y,  Aki D, Kurosaki T,  and  Yoshimura  A; The B cell-specific major raft protein, Raftlin is necessary for the integrity of lipid raft and BCR signal transduction. EMBO J   2003, 22:3015-3026

 

Hanada T, Kinjyo I, Inagaki-Ohara K, Yoshimura A. Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases. Rev Physiol Biochem Pharmacol  2003; 149: 72-86

 

Sasaki,A, Taketomi T, Kato R, Saeki K, Nonami A,  Sasaki M, Kuriyama M,Saito N,Shibuya M, Yoshimura A. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 Nature Cell Biol. 2003, 5:427-432.

 

Shibata R, Kai H, Seki Y, Kato S, Wada Y, Hanakawa Y, Hashimoto K, Yoshimura A, Imaizumi T. Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. Human Gene Therapy  2003, 14: 601-610.

 

Nagata T, Kai H, Shibata R, Koga M, Yoshimura A, Imaizumi T. Oncostatin M, an IL-6 family cytokine, upregulates matrix metalloproteinase-9 through the MEK-ERK pathway in cultured smooth miscle cells. Arteriosclerosis, Thrombosis, Vascular Biology  2003, 23: 588-593.

 

Minoguchi S, Minoguchi M, Yoshimura A. Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation. Biochem Biophys Res Commun. 2003;301: 899-906.

 

Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU.  The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury.  J Clin Invest. 2003, 111: 469-478.

 

Matsumoto A, Seki YI, Watanabe R, Hayashi K, Johnston JA, Harada Y, Abe R, Yoshimura A, Kubo M. A Role of Suppressor of Cytokine Signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated Interleukin 2 Production. J Exp Med. 2003, 197: 425-436.

 

Du L, Frick GP, Tai LR, Yoshimura A, Goodman HM. Interaction of the growth hormone receptor with cytokine-induced SRC homology domain 2 protein in rat adipocytes. Endocrinology  2003, 144: 868-876.

Endo T, Sasaki A, Minoguchi M, Joo A, and Yoshimura A. CIS1 interacts with the Y532 of the Prolactin Receptor and Suppresses Prolactin-Dependent STAT5 Activation 2003. J. BioChem 133, 109-113

 

Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A. STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.  J Biol Chem. 2003 278: 11182-11189

 

Sasaki A, Inagaki-Ohara K, Yoshida T, Yamanaka A, Sasaki M, Yasukawa H, Koromilas AE,Yoshimura A. The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J Biol Chem. 2003 278:2432-2436

 

Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Ronnstrand L. The adapter protein APS associates to the multifunctional docking sites Tyr568 and Tyr936 in c-Kit: possible role in v-Kit transformation. Biochem J.  2003 , 370 1033-1038

 

Yamada S, Shiono S, Joo A, Yoshimura A.  Control mechanism of JAK/STAT signal transduction pathway. FEBS Lett. 2003 ;534:190-196.

 

Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I,Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F. SHP2 and SOCS3 contribute to Y759-dependent attenuation of IL-6-signaling through gp130. J Biol Chem. 2003  278: 661-671

 

Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Biochem Biophys Res Commun. 2003;302:767-772.

 

Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Cell Cycle. 2003;2(4):281-282.

 

 

(2002) -17

Okamoto T, Yamagishi SI, Inagaki Y, Amano S, Koga K, Abe R, Takeuchi M, Ohno S, Yoshimura A, Makita Z. Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin. FASEB J.  2002  16:1928-1930.

 

Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, and Yoshimura A SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation. Immunity 2002, 17: 583-591

 

Seki YI, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.Proc Natl Acad Sci U S A. 2002, 99; 13003-13008

 

Okamoto T, Yamagishi S, Inagaki Y, Amano S, Takeuchi M, Kikuchi S, Ohno S, Yoshimura A. Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro. Biochem Biophys Res Commun. 2002 ;297:419-424.

 

Hanada T and Yoshimura A Regulation of cytokine signaling and inflammation  Cytokine and Growth Factor Reviews, 2002; 13 : 413-421.

 

Yoshida T, Hanada T, Tokuhisa T, Kosai K,  Sata M, Kohara M, Yoshimura A Activation of STAT3 by the Hepatitis C virus core protein leads to cellular transformation J. Exp. Med. 2002 196: 641-653.

 

Nagai H, Kim Y, Konishi N, Baba M, Kubota T, Yoshimura A, Emi M. Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas. Cancer Lett. 2002, 186:59-65.

 

Ben-Yair L, Slaaby R, Herman A, Cohen Y, Biener E, Moran N, Yoshimura A, Whittaker J, De Meyts P, Herman B, Gertler A. Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins. Protein Expr Purif. 2002 ;25: 456-464.

 

Biener E, Maurice S, Sandowski Y, Cohen Y, Gusakowsky EE, Hooghe R, Yoshimura A, Livnah O, Gertler A Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization. Protein Expr Purif. 2002; 25:305-312.

 

Berlato C, Cassatella MA, Kinjyo I, Gatto L, Yoshimura A, Bazzoni F. Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation.  J Immunol. 2002;168:6404-6411.

 

Gasperini S, Crepaldi L, Calzetti F, Gatto L, Berlato C, Bazzoni F, Yoshimura A, Cassatella MA. Interleukin-10 and cAMP-elevating agents cooperate to induce suppressor of cytokine signaling-3 via a protein kinase A-independent signal. Eur Cytokine Netw. 2002 13:47-53.

 

Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H. The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes. J Immunol. 2002;168:2288-95

 

Foley HA, Ofori-Acquah SF, Yoshimura A, Critz S, Baliga BS, Pace BS.  Stat3beta Inhibits gamma globin gene expression in erythroid cells. J Biol Chem. 2002; 277:16211-16219.

 

Tonko-Geymayer S., Goupille O, Tonko M., Soratro C, Yoshimura A, Streuli C., Ziemiecki A., Kofler R, and Soppler W.  Regulation and function of the cytokine inducible SH-2 domain proteins CIS and SOCS3 in mammary epithelial cells Mol. Endocrinol. 2002 ;16:1680-1695

 

Flodstrom M, Maday A, Balakrishna D, Cleary MM, Yoshimura A and Sarvetnick N; Antiviral defenses expressed by the pancreatic b cell govern the development of type 1 diabetes after Coxsackievirus B4 infection. Nature Immunology 3 : 373-382, 2002.

 

Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, and Mak TW, Yoshimura A, Nomoto K and Yoshida H; The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes. J Immunol 168 : 2288-95, 2002.

 

Ohtsuka S, Takaki S, Iseki S, Miyoshi K, Nakagata N, Kataoka Y, Yoshida N, Takatsu K and Yoshimura A; SH2-B is Required for both Male and Female Reproduction. Mol Cell Biol 22 :  3066-3077, 2002.

 

(2001) -10

Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R and Yoshimura A; Spred, a Sprouty-related suppressor of Ras signaling. Nature 412 : 647-651, 2001.

 

Shouda T, Yoshida T, Hanada T, Wakioka T, Oishi M, Miyoshi K, Komiya S, Kosai K, Hanakawa Y, Hashimoto K, Nagata K and Yoshimura A; Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis J Clin Invest 108 : 1781-1788, 2001.

 

Hanada T, Yoshida T, Kinjyo I, Minoguchi S, Yasukawa H, Kato S, Mimata H, Nomura Y, Seki Y, Kubo M and Yoshimura A; A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box. J Biol Chem 276 : 40746-40754, 2001.

 

Sasaki A, Taketomi T, Wakioka T, Kato R and Yoshimura A; Identification of a dominant negative form of Sproutys that potentiates FGF- but not EGF-induced ERK activation. J Biol Chem 276 : 36804-36808, 2001.

 

Yokouchi M, Kondo T, Sanjay A, Houghton A, Yoshimura A, Komiya S, Zhang H and Baron R; Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. J Biol Chem 276 : 35185-35193, 2001.

 

Yasukawa H, Hoshijima M, Gu Y, Nakamura T, Pradervand S, Hanada T, Hanakawa Y, Yoshimura A, Ross J Jr and Chien KR; SOCS3 is a biomechanical stress inducible gene that suppresses gp130 mediated cardiac myocyte hypertrophy and survival pathways J Clin Invest 108 : 1459-1467, 2001.

 

Hamanaka I, Saito Y, Yasukawa H, Kishimoto I, Kuwahara K, Miyamoto Y, Harada M, Ogawa E, Kajiyama N, Takahashi N, Izumi T, Kawakami R, Masuda I, Yoshimura A and Nakao K; Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 Is Involved in gp130 Resistance in Cardiovascular System in Rat Treated With Cardiotrophin-1 In Vivo. Circ Res 88 : 727-732, 2001.

 

Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, Kubo M, Yamashita A, Okabe M, Takeda K, Akira S, Matsumoto S, Toyonaga A, Sata M and Yoshimura A; CIS3/SOCS3/SSI3 Plays a Negative Regulatory Role in STAT3 Activation and Intestinal Inflammation. J Exp Med 193 : 471-482, 2001.

 

Kamizono S, Hanada T, Yasukawa H, Minoguchi S, Kato R, Minoguchi M, Hattori K, Morita S, Kitamura T, Kato H, Nakayama K and Yoshimura A; The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J Biol Chem 276 : 12530-12538, 2001.

 

Sporri B, Kovanen P.E, Sasaki A, Yoshimura A and Leonard WJ; JAB/SOCS1/SSI-1 is an IL-2-induced inhibitor of IL-2 signaling. Blood 97 : 221-226, 2001.

 

 

(2000)  -8

Sakamoto H, Kitamura T and Yoshimura A; Mitogen-Activated Protein Kinase Plays an Essential Role in the Erythropoietin-Dependent Proliferation of CTLL-2 Cells. J Biol Chem 275 : 35857-35862, 2000.

 

Iwamoto T, Senga T, Naito Y, Matsuda S, Miyake Y, Yoshimura A and Hamaguchi M; The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation. Oncogene 19 : 4795-801, 2000.

 

Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I and Yoshimura A; CIS3/SOCS3 suppresses erythropoietin signaling by binding the EPO receptor and JAK2. J Biol Chem 275 : 29338-29347, 2000.

 

Seki Y, Kai H, Shibata R, Nagata T, Yasukawa H, Yoshimura A and Imaizumi T; Role of the JAK/STAT Pathway in Rat Carotid Artery Remodeling After Vascular Injury. Circ Res  87 : 12-18, 2000.

 

Supino-Rosin L, Yoshimura A, Yarden Y, Elazar Z and Neumann D; Intracellular Retention and Degradation of the Epidermal Growth Factor Receptor - Two Distinct Processes Mediated by Benzoquinone Ansamycins. J Biol Chem 275 : 21850-21855, 2000.

 

Yasukawa H, Sasaki A and Yoshimura A; Negative Regulation of Cytokine Signaling Pathways. Annu Rev Immunol 18 : 143-164, 2000.

 

Matsuda T, Yamamoto T, Kishi H, Yoshimura A and Muraguchi A; SOCS-1 can suppress CD3zeta- and Syk-mediated NF-AT activation in a non-lymphoid cell line. FEBS Lett 472 : 235-240. 2000.

 

Ward AC, Touw I and Yoshimura A; The jak-stat pathway in normal and perturbed hematopoiesis. Blood 95 : 19-29, 2000.

 

(<1999)

Marine J-C, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A and Ihle JN; SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis. Cell 98 : 617-627, 1999.

 

Marine J-C, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A and Ihle JN; SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality. Cell 98 : 609-616, 1999.

 

Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A and Baron R; Ligand-induced Ubiquitination of the EGF Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7. J Biol Chem 274 : 31707-31712, 1999.

 

Supino-Rosin L, Yoshimura A, Altaratz H and Neumann D; A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation. Eur J Biochem 263 : 410-419, 1999.

 

Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu Mh, Soldaini E, Imada K, Miyajima A, Yoshimura A and Leonard WJ; CIS Associates with the Interleukin-2 Receptor beta Chain and Inhibits IL-2-Dependent Signaling. J Biol Chem 274 : 30266-30272, 1999.

 

Cassatella MA, Gasperini S, Bovolenta C, Calzetti F, Vollebregt M, Scapini P, Marchi M, Suzuki R, Suzuki A and Yoshimura A; Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10-Induced Pathway That Is Independent of STAT Protein Activation. Blood 94 : 2880-2889, 1999.

 

Cohney SJ, Sanden D, Cacalano NA, Yoshimura A, Mui A, Migone TS and Johnston JA; SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation. Mol Cell Biol 19 : 4980-4988, 1999.

 

Matsumoto A, Seki Y, Kubo M, Ohtsuka S, Suzuki A, Hayashi I, Tsuji K, Nakahata T, Okabe M, Yamada S and Yoshimura A; Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice. Mol Cell Biol 19 : 6396-6407, 1999.

 

Chida D, Miura O, Yoshimura A and Miyajima A; Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression. Blood 93 : 1567-1578, 1999.

 

Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka A, Imaizumi T, Matsuda T, Ihle JN and Yoshimura A; The JAK-Binding Protein JAB Inhibits Janus Tyrosine Kinase Activity Through Binding in the Activation Loop. EMBO J 18 : 1309-1320, 1999.

 

Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S and Yoshimura A; APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl, and inhibits PDGF-induced mitogenesis. Oncogene 18 : 759-768, 1999.

 

Okajima Y, Matsumura I, Nishiura T, Hashimoto K, Yoshida H, Ishikawa J, Wakao H, Yoshimura A, Kanakura Y, Tomiyama Y and Matsuzawa Y; Insulin-like growth factor-I augments erythropoietin-induced proliferation through the enhanced tyrosine phosphorylation of STAT5. J Biol Chem 273 : 22877-22883, 1998.

 

Verdier F, Chretien S, Muller O, Varlet P, Yoshimura A, Gisselbrecht S, Lacombe C and Mayeux P; Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation. J Biol Chem 273 : 28185-28190, 1998.

 

Chida D, Wakao H, Yoshimura A and Miyajima A; Transcriptional regulation of the b-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules. Mol Endocrinol 12 : 1792-1806, 1998.

 

Sakamoto H, Yasukawa H, Masuhara M, Tanimura S, Sasaki A, Yuge K, Ohtsubo M, Ohtsuka S, FujitaT, Ohta T, Furukawa Y, Iwase S, Yamada H and Yoshimura A; A Janus kinase inhibitor, JAB, is an interferon-g inducible gene and confers resistance to interferons. Blood 92 : 1668-1676, 1998.

 

Suzuki R, Sakamoto H, Yasukawa H, Masuhara M, Wakioka T, Sasaki A, Yuge K, Yokouchi M, Komiya S, Inoue A and Yoshimura A; CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. Oncogene 17 : 2271-2278, 1998.

 

Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanekura Y, Komiya S and Yoshimura A; A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 : 921-924, 1997.

 

Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, Miyajima A and Yoshimura A; CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89 : 3148-3154, 1997.

 

Iwatsuki K, Endo T, Misawa H, Yokouchi M, Matsumoto A, Ohtsubo M, Mori JK and Yoshimura A; STAT5 Activation Correlates with Erythropoietin Receptor-Mediated Erythroid Differentiation of an Erythroleukemia Cell Line. J Biol Chem 272 : 8149-8153, 1997.

 

Yokouchi, M., Suzuki, R., Masuhara, M., Komiya, S., Inoue, A., and Yoshimura, A. Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. 

Oncogene   15, 7-15, 1997

 

Yoshimura, A, Ichihara, M., Kinjyo, I., Moriyama, M., Copeland, N.G., Gilbert, D.J., Jenkins, N.A.,      Hara, T., Miyajima, A.  :Mouse oncostatin M: an immediate early response gene induced by multiple cytokines through the JAK/STAT5 pathway.  EMBO J. 15, 1055-1063, 1996  

 

Yoshimura, A. , Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T., and Miyajima, A. :  A novel cytokine-inducible gene  CIS encodes an SH2-contanining protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14, 2816-2826, 1995

 

Hara, T., Bacon,K.B., Cho, L.C., Yoshimura, A., Morikawa, Y., Copeland, N.G.,  Miyajima A., et al.:  Molecular cloning and functional characterization of a novel member of the C-C chemokine family.   J. Immunol.  155,  5352-5358, 1995 

 

Yoshimura, A :  Second subunit of EPO receptor? Nature 372, 137-138, 1994

 

Ohashi, H., Maruyama, K., Liu, Y. and  Yoshimura, A.:  Ligand-induced  activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases.   Proc. Natl. Acad. Sci. USA.   91, 158-162, 1994

 

Maruyama, K., Miyata, K., and  Yoshimura, A. : Proliferation and erythroid differentiation  through the cytoplasmic domain of the erythropoietin receptor. J. Biol. Chem.  269, 5976-5980, 1994

 

Youssoufian, H., Logmore, G., Newmann, D., Yoshimura, A., Lodish, H. F.:  Structure, function, and activation of the erythropoietin receptor.  Blood 81, 2223-2236, 1993

 

Yoshimura, A. and Lodish, H. F.:  In vitro phosphorylation of the erythropoietin receptor and an associated protein,  pp130.  Mol. Cell. Biol.  12,  706-715, 1992

 

Watowich, S. S., Yoshimura, A., Longmore, G., Hilton, D. J., Yoshimura, Y., and Lodish, H. F.: Homodimerization and constitutive activation of the erythropoietin receptor. Proc. Natl. Acad. Sci. USA. 89, 2140-2144, 1992

 

Yoshimura, A., Zimmers, T., Neumann, D., Longmore, G., Yoshimura, Y.,and  Lodish,  H. F.: Mutations in theTtp-Ser-X-Trp-Ser motif  of the erythropoietin receptor abolish  processing, ligand binding, and activation of the receptor. 

J. Biol. Chem.  267, 11619-11625, 1992

 

Yoshimura, A., Longmore, G. and Lodish, H. F.:  Point mutation in the exoplasmic  domain of the erythropoietin receptor resulting in hormone-independent  activation and  tumorigenecity.  Nature 348, 647-649, 1990

 

Yoshimura, A., D'Andrea, A. D. and Lodish, H. F.:  Friend spleen focus forming virus  glycoprotein gp55 interacts with  erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.  Proc. Natl. Acad. Sci. USA. 87, 4139-4143, 1990

 

Fuji, R., Mutho, M., Sumizawa, T., Chen, Z., Yoshimura, A., and Akiyama, S. Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells.  J. Natl. Cancer Inst. 86, 1781-1784, 1994

 

Sumizawa, T., Furukawa, T., Haraguchi, M., Yoshimura, A., Takeyasu, A., Ishizawa, M, Yamada, Y., and Akiyama, S.  Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor.  J. Biochem. 114, 9-14, 1993

 

Ichikawa-Haraguchi, M., Sumizawa, T., Yoshimura, A., Furukawa, T., Hiramoto, S., Sugita, M., and Akiyama, S.   Progesterone and its metabolites: the potent inhibitors of the transporting activity of P-glycoprotein in the adrenal gland.     Biochim. Biophys. Acta  1158, 201-213, 1993 

 

Nishiyama, K., Shirahama, T., Yoshimura, A., Sumizawa, T., Furukawa, T.,  Ichikawa-Haraguchi, M., Akiyama, S., and Ohi, Y.  Expression of the multidrug transporter, P-glycoprotein, in renal and transitional cell carcinomas. Cancer 71, 3611-3619, 1993

 

Furukawa, T., Yoshimura, A., Sumizawa, T., Haraguchi, M., Akiyama, S., Fukui, K., Ishizawa, M., Yamada, Y.  Angiogenic Factor.  Nature 356, 668, 1992

 

Ichikawa, M., Yoshimura, A., Sumizawa, T., Shudo, N., Kuwazuru, Y., Furukawa, T.  and Akiyama, S. Interaction of organic chemicals with P-glycoprotein in the adrenal grand,  kidney, and a multidrug-resistant KB cell. J. Biol. Chem. 266, 903-908, 1991

 

Ichikawa, M., Yoshimura, A., Furukawa, T., Sumizawa, T., Nakazima, Y.  and Akiyama, S.  Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line, and in the human tissues. Biochim. Biophys. Acta 1073, 309-315, 1991

 

Yoshimura, A., Kuwazuru, Y., Furukawa, T., Yoshida, H., Yamada, K.  and Akiyama, S.  Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors.  Biochim. Biophys. Acta 1034, 107-113, 1990

 

Yoshimura, A., Shudo, N., Ikeda, S., Ichikawa, M.,. Sumizawa, T.,  and Akiyama, S. Novel screening method for agents that overcome classical multidrug resistance in a human cell line.  Cancer Lett. 50, 45-51, 1990

 

Ichikawa, M., Yoshimura, A., Furukawa, T., Sumizawa, T. and  Akiyama, S.  Modulators of the multidrug-transporter, P-glycoprotein, exist in the human   plasma. Biochem. Biophys. Res. Commun. 166, 74-80, 1990

 

Kuwazuru, Y., Yoshimura, A., Hanada, S., Utsunomiya, A., Makino, T., Ishibashi, K., Kodama, M., Iwahashi, M., Arima, T. and Akiyama, S.  Expression of the multidrug transporter, P-glycoprotein, in acute leukemia cells and correlation to clinical drug resistance. Cancer 66, 868-873, 1990

 

Kuwazuru, Y., Yoshimura, A., Hanada, S., Ichikawa, M., Saito, T., Uozumi, K., Utsunomiya, A., Arima, T. and Akiyama, S.  Expression of the multidrug transporter, P-glycoprotein, in chronic myelogenous leukaemia cells in blast crisis.  Br. J. Haematol. 74, 24-29, 1990

 

Kuwazuru, Y., Hanada, S., Furukawa, T., Yoshimura, A., Sumizawa, T., Utsunomiya, A., Ishibashi, K., Saito, T., Uozumi, K., Maruyama, M., Ishizawa, M., Arima, T. and Akiyama, S. Expression of P-glycoprotein in adult T-cell leukemia cells. Blood 76, 2065-2071, 1990

 

Sudo N., Mizoguchi T., Kiyosue, T., Arita, M., Yoshimura, A., Sakoda, R.  and Akiyama, S.  Two pyridine analogues with more effective ability to reverse multidrug-resistance  and with lower calcium channel blocking activity than their dihydropyridine counterparts. Cancer Res. 50, 3055-3061, 1990

 

Ikeda, S., Sugita, M., Yoshimura, A., Sumizawa, T., Douzono, H.,  Nagata, Y. and Akiyama, S.  Aspergillus species strain M39 produces two naphtho-gamma-pyrones that  reverse drug resistance in human KB cells. Int. J. Cancer  45, 508-513, 1990

 

Yoshimura, A., Kuwazuru, Y., Sumizawa, T., Ichikawa, M., Ikeda, S., Ueda, T. and Akiyama, S. Cytoplasmic orientation and two-domain structure of the multidrug transporter,  P-glycoprotein, demonstrate with sequence specific antibodies.

J. Biol. Chem. 264, 16202-16291, 1989

 

Yoshimura, A., Kuwazuru, Y., Sumizawa, T., Ikeda, S., Ichikawa, M., Usagawa, T. and Akiyama, S.  Biosynthesis, processing. and half-life of P-glycoprotein in a human multidrug-resistant KB cell.  Biochim. Biophys. Acta 992, 307-314,1989

 

Seguchi, T., Yoshimura, A., Ono, M., Shite, S., Kasahara, M., Ebina, Y., Rutter, W. J., and Kuwano, M.  Insulin receptor and altered glucose transport in a monensin-resistant mutant of  Chinese hamster ovary cell. J. Cell Physiol. 139, 229-236, 1989

 

Akiyama, S., Yoshimura, A., Kikuchi, H., Sumizawa, T., Kuwano, M. and Tahara, Y. Synthetic isoprenoid photoaffinity labeling of P-glycoprotein specific to multidrug- resistant cells. Mol. Pharmacol. 36, 730-735, 1989

 

Kamiwatari, M., Nagata, Y., Kikuchi, H., Yoshimura, A., Sumizawa, T., Shudo, N. Sakoda, R., Seto, K. and Akiyama, S. Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line.  Cancer Res. 49, 3190-3195, 1989

 

Yoshimura, A., Seguchi, T., Yoshida, T., Waki, M. and Kuwano, M.   Nobel feature of metabolism of low density lipoprotein receptor in a mouse macrophage cell line, J774.1. J. Biol. Chem. 263, 11935-11942, 1988

 

Hagino, Y. Mawatari, M., Yoshimura, A., Kohno, K., Kobayashi, M. and Kuwano, M.  Estrogen inhibits the growth of MCF-7 cell variants resistant to transforming growth factor-beta. Jap. J. Cancer. Res. (Gann) 79, 74-81, 1988   

 

Yoshimura, A., Yoshida, T., Waki, M., Seguchi, T., Ono, M. and Kuwano, M.  Low binding capacity and altered O-linked glycosylation of low density lipoprotein receptor in a monensin-resistant mutant of Chinese hamster ovary cells. 

 J. Biol. Chem. 262, 13299-13308, 1987

 

Yoshimura, A., Kobayashi, T., Hidaka, K., Kuwano, M. and Ohnishi, S.  Altered interaction between Sendai virus and a Chinese hamster cell mutant with defective cholesterol synthesis.  Biochim. Biophys. Acta 904, 157-164, 1987

 

Yoshida, T., Yoshimura, A., Ono, M., Hori, S. and Kuwano, M.  Altered structure and function of low density lipoprotein receptor in compactin (ML236b) resistant mutants of Chinese hamster cells.   Biochim. Biophys. Acta 921, 575-586, 1987

 

Tomita, K., Yoshida, T., Yoshimura, A., Ono, M. and Kuwano, M. Chinese hamster ovary cell mutants with defective down-regulation of low density lipoprotein receptors.   J. Biol. Chem. 262, 1398-1404, 1987

 

Akiyama, S., Shiraishi, N., Yoshimura, A., Nakagawa, M., Yamaguchi, T., Shimada, T. and Kuwano, M.  Enhancement by a synthetic isoprenoid of the toxicity of conjugates of epidermal  growth factor with Pseudomonas exotoxin.

 Biochem. Pharmacol. 36, 861-868, 1987

 

Yoshimura, A.   Adenovirus-induced leakage of co-endocytosed macromolecules into the cytosol. Cell Struct. Fanct. 10, 391-404, 1985 

 

Yoshimura, A., Yamashina, S. and Ohnishi, S.   Mobilization and aggregation of integral membrane proteins in erythrocytes induced by interaction with influenza virus at acidic pH. Exp. Cell. Res. 160, 126-137, 1985

 

Ono, M., Mifune, K., Yoshimura, A., Ohnishi, S. and Kuwano, M.  Monensin-resistant mouse Balb/3T3 cell mutant with aberrant penetration of  vesicular stomatitis virus. J. Cell. Biol. 101, 60-65, 1985

 

Yoshimura, A. and Ohnishi, S. Uncoating of influenza virus in endosome. 

J. Virol. 51, 497-504, 1984

 

Yoshimura, A., Kuroda, K., Kawasaki, K., Yamashina, S., Maeda, T. and Ohnishi, S. Infectious cell entry mechanism of influenza virus.  J. Virol. 43, 284-293, 1982

 

 

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