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(2015) 


A gp130-Src-YAP module links inflammation to epithelial regeneration.
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. Nature. 2015 Mar 5;519(7541):57-62.. doi: 10.1038/nature14228.

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.
Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):160-5. doi: 10.1073/pnas.1413234112. 

Anti-IL-12/23 p40 Antibody Attenuates Experimental Chronic Graft-versus-Host Disease via Suppression of IFN-γ/IL-17-Producing Cells.
Okamoto S, Fujiwara H, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Yoshimura A, Tanimoto M, Maeda Y. J Immunol. 2015 Feb 1;194(3):1357-63. doi: 10.4049/jimmunol.1400973

(2014)
Post-ischemic inflammation regulates neural damage and protection.
Shichita T, Ito M, Yoshimura A.
Front Cell Neurosci. 2014 Oct 14;8:319. doi: 10.3389/fncel.2014.00319. eCollection 2014. Review

SOCS1 and regulation of regulatory T cells plasticity.
Takahashi R, Yoshimura A.
J Immunol Res. 2014;2014:943149. doi: 10.1155/2014/943149.

Lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation.
Okada M, Matsuzawa A, Yoshimura A, Ichijo H.
J Biol Chem. 2014 Nov 21;289(47):32926-36. doi: 10.1074/jbc.M114.579961.

Spred-2 deficiency exacerbates lipopolysaccharide-induced acute lung inflammation in mice.
Xu Y, Ito T, Fushimi S, Takahashi S, Itakura J, Kimura R, Sato M, Mino M, Yoshimura A, Matsukawa A.
PLoS One. 2014 Oct 2;9(9):e108914. doi: 10.1371/journal.pone.0108914. eCollection 2014.

Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis.
Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saitoh K, Yoshimura A, Matsuda T, Kanakura Y.
Eur J Immunol. 2014 Jun;44(6):1791-801. doi: 10.1002/eji.201344239. Epub 2014 Apr 15.

Loss of Sprouty4 in T cells ameliorates experimental autoimmune encephalomyelitis in mice by negatively regulating IL-1β receptor expression.
Fukaya T, Someya K, Hibino S, Okada M, Yamane H, Taniguchi K, Yoshimura A.
Biochem Biophys Res Commun. 2014 May 9;447(3):471-8. doi: 10.1016/j.bbrc.2014.04.012. Epub 2014 Apr 13.

Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses.
Sekine Y, Nishida K, Yamasaki S, Muromoto R, Kon S, Kashiwakura J, Saitoh K, Togi S, Yoshimura A, Oritani K, Matsuda T.
J Immunol. 2014 Apr 15;192(8):3488-95. doi: 10.4049/jimmunol.1300886. Epub 2014 Mar 10.

Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells.
Takasato F, Morita R, Schichita T, Sekiya T, Morikawa Y, Kuroda T, Niimi M, Yoshimura A.
PLoS One. 2014 Feb 3;9(2):e87722. doi: 10.1371/journal.pone.0087722. eCollection 2014.

A proteomic approach for the elucidation of the specificity of ectodomain shedding.
Shirakabe K, Shibagaki Y, Yoshimura A, Koyasu S, Hattori S.
J Proteomics. 2014 Jan 20. pii: S1874-3919(14)00024-4. doi: 10.1016/j.jprot.2014.01.012

Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation.
Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T.
PLoS One. 2014 Jan 2;9(1):e84619. doi: 10.1371/journal.pone.0084619.

Aryl hydrocarbon receptor protects against bacterial infection by promoting macrophage survival and reactive oxygen species production.
Kimura A, Abe H, Tsuruta S, Chiba S, Fujii-Kuriyama Y, Sekiya T, Morita R, Yoshimura A.
Int Immunol. 2014 Apr;26(4):209-20. doi: 10.1093/intimm/dxt067.

Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction.
Koike K, Ueda S, Yamagishi S, Yasukawa H, Kaida Y, Yokoro M, Fukami K, Yoshimura A, Okuda S.
Clin Immunol. 2014 Jan;150(1):78-87. doi: 10.1016/j.clim.2013.11.003.

Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-γ expression and inducing IL-22.
Abe H, Kimura A, Tsuruta S, Fukaya T, Sakaguchi R, Morita R, Sekiya T, Shichita T, Chayama K, Fujii-Kuriyama Y, Yoshimura A.
Int Immunol. 2014 Mar;26(3):129-37. doi: 10.1093/intimm/dxt049.

(2013) 17
SOCS, inflammation, and cancer.
Inagaki-Ohara K, Kondo T, Ito M, Yoshimura A.
JAKSTAT. 2013 Jul 1;2(3):e24053. Epub 2013 Aug 15. Review.

TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.
Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi T, Luche H, Fehling HJ, Walsh M, Choi Y, Yoshimura A.
PLoS One. 2013 Sep 13;8(9):e74639. doi: 10.1371/journal.pone.0074639.

Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b.
Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, Hamada H, Harada M, Shiokawa Y, Nishida T, Tominaga R, Kikushige Y, Akashi K, Kudoh J, Shimizu N, Tanaka Y, Umemura T, Taniguchi T, Yoshimura A, Kobayashi T, Mitsuyama M, Kurisaki H, Katsuta H, Nagafuchi S.
Gene. 2013 Nov 1;530(1):19-25. doi: 10.1016/j.gene.2013.08.015. Epub 2013 Aug 14.

Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging.
Nishimura H, Ritchie K, Kasai RS, Goto M, Morone N, Sugimura H, Tanaka K, Sase I, Yoshimura A, Nakano Y, Fujiwara TK, Kusumi A.
J Cell Biol. 2013 Sep 16;202(6):967-83. doi: 10.1083/jcb.201301053.

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis.
Venken K, Seeuws S, Zabeau L, Jacques P, Decruy T, Coudenys J, Verheugen E, Windels F, Catteeuw D, Drennan M, Van Calenbergh S, Lambrecht BN, Yoshimura A, Tavernier J, Elewaut D.
J Hepatol. 2013 Aug 20. doi:pii: S0168-8278(13)00597-7. 10.1016/j.jhep.2013.08.008.

Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-like Skin Inflammation.
Nishimoto S, Kotani H, Tsuruta S, Shimizu N, Ito M, Shichita T, Morita R, Takahashi H, Amagai M, Yoshimura A.
J Immunol. 2013 Sep 15;191(6):3065-72. doi: 10.4049/jimmunol.1300348.

Smad2/3 and IRF4 Play a Cooperative Role in IL-9-Producing T Cell Induction.
Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, Shichita T, Honma K, Yui K, Matsuyama T, Nakao T, Fukuyama S, Inoue H, Nomura M, Yoshimura A.
J Immunol. 2013 Sep 1;191(5):2360-71. doi: 10.4049/jimmunol.1301276.

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.
Carow B, Reuschl AK, Gavier-Widén D, Jenkins BJ, Ernst M, Yoshimura A, Chambers BJ, Rottenberg ME.
PLoS Pathog. 2013 Jul;9(7):e1003442. doi: 10.1371/journal.ppat.1003442.

IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages.
Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, Hisaeda H.
Eur J Immunol. 2013 Jul 10. doi: 10.1002/eji.201343493.

CIS: the late-blooming eldest son.
Yoshimura A.
Nat Immunol. 2013 Jul;14(7):692-4. doi: 10.1038/ni.2645.

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.
Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hibi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T.
Cell Host Microbe. 2013 Jun 12;13(6):711-22. doi: 10.1016/j.chom.2013.05.013.

CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice.
Yoshida H, Kotani H, Kondo T, Tani I, Wei X, Tsuruta S, Kimura A, Asakawa M, Ito M, Nagai S, Yoshimura A.
Biochem Biophys Res Commun. 2013 Jun 7;435(3):378-84. doi: 10.1016/j.bbrc.2013.04.096.

CLP1 links tRNA metabolism to progressive motor-neuron loss.
Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM.
Nature. 2013 Mar 28;495(7442):474-80. doi: 10.1038/nature11923.

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H.
J Clin Invest. 2013 Mar 1;123(3):1019-31. doi: 10.1172/JCI64931.

Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A.
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.
Nature Immunol. 2013 2013 Jan 20;14(3):230-7. Jan 20. doi: 10.1038/ni.2520. [Epub ahead of print]

Romain M, Taleb S, Dalloz M, Ponnuswamy P, Esposito B, Pérez N, Wang Y, Yoshimura A, Tedgui A, Mallat Z. Overexpression of SOCS3 in T Lymphocytes Leads to Impaired Interleukin-17 Production and Severe Aortic Aneurysm Formation in Mice--Brief Report.
Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):581-4. doi: 10.1161/ATVBAHA.112.300516.

Hasegawa E, Sonoda KH, Shichita T, Morita R, Sekiya T, Kimura A, Oshima Y, Takeda A, Yoshimura T, Yoshida S, Ishibashi T, Yoshimura A.
IL-23-Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization.
J Immunol. 2013 Feb 15;190(4):1778-87. doi: 10.4049/jimmunol.1202495. Epub 2013 Jan 14.

(2012) 20

Yan X, Shichita T, Katsumata Y, Matsuhashi T, Ito H, Ito K, Anzai A, Endo J, Tamura Y, Kimura K, Fujita J, Shinmura K, Shen W, Yoshimura A, Fukuda K, Sano M.
Deleterious Effect of the IL-23/IL-17A Axis and γδT Cells on Left Ventricular Remodeling After Myocardial Infarction.
J Am Heart Assoc. 2012 Oct;1(5):e004408. doi: 10.1161/JAHA.112.004408. Epub 2012 Oct 25.

Takaesu G, Inagaki M, Takubo K, Mishina Y, Hess PR, Dean GA, Yoshimura A, Matsumoto K, Suda T, Ninomiya-Tsuji J.
TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms.
PLoS One. 2012;7(11):e51073. doi: 10.1371/journal.pone.0051073.

Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A.
Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.
Oncogene. 2012 Nov 26. doi: 10.1038/onc.2012.540

Shichita T, Ago T, Kamouchi M, Kitazono T, Yoshimura A, Ooboshi H.
Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke.
J Neurochem. 2012 Nov;123 Suppl 2:29-38. doi: 10.1111/j.1471-4159.2012.07941.x. Review.

Shichita T, Hasegawa E, Kimura A, MoritaR, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, and Yoshimura A
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
Nature Medicine 2012 Jun;18(6):911-7. doi: 10.1038/nm.2749.

Shichita T, Sakaguchi R, Suzuki M, Yoshimura A.
Post-Ischemic Inflammation in the Brain.
Front Immunol. 2012;3:132. doi: 10.3389/fimmu.2012.00132. Epub 2012 May 31.Review

Wakabayashi H, Ito T, Fushimi S, Nakashima Y, Itakura J, Qiuying L, Win MM, Cuiming S, Chen C, Sato M, Mino M, Ogino T, Makino H, Yoshimura A, Matsukawa A.
Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice.
Clin Immunol. 2012 Jul 14;144(3):272-282. doi: 10.1016/j.clim.2012.07.002.

Uto-Konomi A, Miyauchi K, Ozaki N, Motomura Y, Suzuki Y, Yoshimura A, Suzuki S, Cua D, Kubo M.
Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines.
PLoS One. 2012;7(7):e40343. doi: 10.1371/journal.pone.0040343. Epub 2012 Jul 5.

Yoshida R, Suzuki M, Sakaguchi R, Hasegawa E, Kimura A, Shichita T, Sekiya T, Shiraishi H, Shimoda K, Yoshimura A.
Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo.
Biochem Biophys Res Commun. 2012 Jun 29;423(2):247-52. doi: 10.1016/j.bbrc.2012.05.097. Epub 2012 May 24.

Sekine Y, Yamamoto C, Kakisaka M, Muromoto R, Kon S, Ashitomi D, Fujita N, Yoshimura A, Oritani K, Matsuda T.
Signal-transducing adaptor protein-2 modulates fas-mediated T cell apoptosis by interacting with caspase-8.
J Immunol. 2012 Jun 15;188(12):6194-204. doi: 10.4049/jimmunol.1103467. Epub 2012 May 18.

Kawano Y, Nakae J, Watanabe N, Fujisaka S, Iskandar K, Sekioka R, Hayashi Y, Tobe K, Kasuga M, Noda T, Yoshimura A, Onodera M, Itoh H.
Loss of pdk1-foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.
Diabetes. 2012 Aug;61(8):1935-48. doi: 10.2337/db11-0770.

Yoshida H, Suzuki M, Sakaguchi R, Tani I, Kotani H, Shudo N, Yoshimura A.
Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi).
Biochem Biophys Res Commun. 2012 May 25;422(1):174-80. doi: 10.1016/j.bbrc.2012.04.135. Epub 2012 May 1.

Yoshimura A, Suzuki M, Sakaguchi R, Hanada T, Yasukawa H.
SOCS, Inflammation, and Autoimmunity. Review
Front Immunol. 2012;3:20. doi: 10.3389/fimmu.2012.00020. Epub 2012 Mar 12.

Yoshimura A, Yasukawa H.
JAK's SOCS: a mechanism of inhibition.
Immunity. 2012 Feb 24;36(2):157-9. doi: 10.1016/j.immuni.2012.01.010.

Sugiyama Y, Kakoi K, Kimura A, Takada I, Kashiwagi I, Wakabayashi Y, Morita R, Nomura M, Yoshimura A. Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways. Int Immunol. 2012 Apr;24(4):253-65. doi: 10.1093/intimm/dxr126

Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A.
Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.
Biochem Biophys Res Commun. 2012 Feb 10;418(2):234-40. doi: 10.1016/j.bbrc.2011.12.156. Epub 2012 Jan 9.

Saeki K, Kanai T, Nakano M, Nakamura Y, Miyata N, Sujino T, Yamagishi Y, Ebinuma H, Takaishi H, Ono Y, Takeda K, Hozawa S, Yoshimura A, Hibi T.
CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice.
Gastroenterology. 2012 Apr;142(4):1010-1020.e9. doi: 10.1053/j.gastro.2011.12.054. Epub 2012 Jan 13.

Sekine Y, Ikeda O, Mizushima A, Ueno Y, Muromoto R, Yoshimura A, Kanakura Y, Oritani K, Matsuda T.STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.
Oncogene. 2012 31(40):4384-96. doi: 10.1038/onc.2011.604. Jan 9. doi: 10.1038/onc.2011.604.

Takaesu G, Kobayashi T, Yoshimura A.
TGF{beta}-Activated Kinase 1 (TAK1)-Binding Proteins (TAB) 2 and 3 Negatively Regulate Autophagy.
J Biochem. Feb;151(2):157-66. doi: 10.1093/jb/mvr123. Epub 2011 Oct 5.

(2011) 24
Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao A, Yoshimura A.
Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.
J Immunol. 2011 Nov 1;187(9):4611-20. Epub 2011 Sep 28.

Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A.
IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.
Int Immunol. 2011 Nov;23(11):701-12. Epub 2011 Sep 21.

Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Asakawa M, Chinen T, Yoshimura A.
SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production.
J Exp Med. 2011 Sep 26;208(10):2055-67. Epub 2011 Sep 5.

Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T, Kuwana M, Fujii H, Koyasu S, Amagai M.
Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice.
J Clin Invest. 2011 Sep 1;121(9):3677-88. doi: 10.1172/JCI57379. Epub 2011 Aug 8.

Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, Ichiyama K, Yoshimura A, Steinman L, Christakos S, Youssef S.
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A.
Mol Cell Biol. 2011 Sep;31(17):3653-69. Epub 2011 Jul 11.

Wakabayashi Y, Tamiya T, Takada I, Fukaya T, Sugiyama Y, Inoue N, Kimura A, Morita R, Kashiwagi I, Takimoto T, Nomura M, Yoshimura A.
Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway.
J Biol Chem. 2011 Oct 14;286(41):35456-65. Epub 2011 Aug 23.

Carow B, Qun Ye X, Gavier-Widén D, Bhuju S, Oehlmann W, Singh M, Sköld M, Ignatowicz L, Yoshimura A, Wigzell H, Rottenberg ME. Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-{gamma} (IFN-{gamma})-dependent Manner. J Biol Chem. 2011 Jul 29;286(30):26873-87.

Ishizaki T, Tamiya T, Taniguchi K, Morita R, Kato R, Okamoto F, Saeki K, Nomura M, Nojima Y, Yoshimura A. miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1. Genes Cells. 2011 Jul;16(7):803-814. doi: 10.1111/j.1365-2443.2011.01529.x

Hiwatashi K, Tamiya T, Hasegawa E, Fukaya T, Hashimoto M, Kakoi K, Kashiwagi I, Kimura A, Inoue N, Morita R, Yasukawa H, Yoshimura A. Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction. Cancer Lett. 2011 Sep 28;308(2):172-80. Epub 2011 May 31.

Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Littman DR, Hibi T. Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells. Gastroenterology. 2011 Sep;141(3):1014-23. Epub 2011 Jun 7.

Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A.
Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin.
Immunity. 2011 May 27;34(5):741-54.

Tamiya T, Kashiwagi I, Takahashi R, Yasukawa H, Yoshimura A.
Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways: Regulation of T-Cell Inflammation by SOCS1 and SOCS3.
Arterioscler Thromb Vasc Biol. 2011 May;31(5):980-5.

Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H.
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Cancer Cell. 2011 Apr 12;19(4):456-69.

Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A.
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.
Nature Commun. 2011;2:269.

Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H, Sekiya T, Yoshida R, Nakamura K, Takayanagi R, Yoshimura A; Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nature Commun 2,E190, 2011 doi:10.1038/ncomms1181

Nakaya M, Hamano S, Kawasumi M, Yoshida H, Yoshimura A, Kobayashi T.; Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations. Int Immunol. 2011 Mar;23(3):195-202.

Hashimoto M, Hiwatashi K, Ichiyama K, Morita R, Sekiya T, Kimura A, Sugiyama Y, Sibata T, Kuroda K, Takahashi R, Yoshimura A.; SOCS1 regulates type I/type II NKT cell balance by regulating IFN{gamma} signaling. Int Immunol. 2011 Mar;23(3):165-76.

Metlakunta AS, Sahu M, Yasukawa H, Dhillon SS, Belsham DD, Yoshimura A, Sahu A;
Neuronal suppressor of cytokine signaling-3 (Socs3) deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase (PI3K) signaling. Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1185-93. Epub 2011 Feb 16.

Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M; Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J Biol Chem. 2011 Mar 25;286(12):10702-11.

Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells. Cancer Sci. 2011 Apr;102(4):756-61. doi: 10.1111/j.1349-7006.2010.01842.x.
Matsumura K, Taketomi T, Yoshizaki K, Arai S, Sanui T, Yoshiga D, Yoshimura A, Nakamura S.; Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling. Biochem Biophys Res Commun. 2011 Jan 28;404(4):1076-82.

Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T, Matsumoto K, Asai Y, Kubo M, Yoshimura A, Nakanishi Y. Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma. Biochem Biophys Res Commun. 2011 Jan 7;404(1):261-7.

Denayer E, Chmara M, Brems H, Kievit AM, van Bever Y, Van den Ouweland AM, Van Minkelen R, de Goede-Bolder A, Oostenbrink R, Lakeman P, Beert E, Ishizaki T, Mori T, Keymolen K, Van den Ende J, Mangold E, Peltonen S, Brice G, Rankin J, Van Spaendonck-Zwarts KY, Yoshimura A, Legius E. Legius syndrome in fourteen families. Hum Mutat. 2011 Jan;32(1):E1985-98. DOI: 10.1002/humu.21404

Moriwaki A, Inoue H, Nakano T, Matsunaga Y, Matsuno Y, Matsumoto T, Fukuyama S, Kan-O K, Matsumoto K, Tsuda-Eguchi M, Nagakubo D, Yoshie O, Yoshimura A, Kubo M, Nakanishi Y.;
T Cell Treatment with Small-interfering RNA for SOCS3 Modulates Allergic Airway Responses in a Murine Model of Asthma. Am J Respir Cell Mol Biol. 2011 Apr;44(4):448-55. doi:10.1165/rcmb.2009-0051OC

Miyamoto R, Jijiwa M, Asai M, Kawai K, Ishida-Takagishi M, Mii S, Asai N, Enomoto A, Murakumo Y, Yoshimura A, Takahashi M.
Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.
Dev Biol. 2011 Jan 15;349(2):160-8
 

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